Sacred Datura Bloom (Datura wrightii)
These plants are exceedingly poisonous, containing varying amounts of tropane alkaloids such as atropine and scopolamine. Native Americans accumulated vast experience with these plants and used them for spiritual ceremonies and such (hence the name). They are not generally used for recreation as the resultant delirium is supposedly highly unpleasant. Plus the part where it might kill you because you ate the wrong leaf...